Karup River (Danish: Karup Å) is a river in central Jutland, Denmark. Prior to 1970, it formed the border between the Viborg and Ringkjøbing counties.
Karup River is Denmarks sixth largest river.
A 500-hectare area along the river, spanning 20 kilometers between Karup and Hagebro, was protected in 1964, and the entire stretch from Karup to Skive, a total of 1,008 hectares (including some tributaries), is now a European Union Special Area of Conservation.
