The Pascoe River is a river in Far North Queensland, Australia.
The headwaters rise under Mount Yangee in the Table Range, part of the Great Dividing Range at the northern end of Cape York Peninsula. The river initially flows south then west past the Sir William Thompson Range then veers north through the mostly uninhabited country. Flowing past Hamilton Hill the river then heads east past Wattle Hill and runs parallel with the Goddard Hills forming the northern border of Kutini-Payamu National Park. The river finally discharges into Weymouth Bay and onto the Coral Sea. From source to mouth, the Pascoe River is joined by eight tributaries including the Little Pascoe River, descending 243 metres over its 119-kilometre course.
The river has a catchment area of 2,124 square kilometres of which an area of 33 square kilometres is composed of riverine wetlands.
The traditional owners of the area are the Kuuku Yau, Kaanju and Umpila people who maintain a strong spiritual connection to the land.
