Tyugyuene
                    General data
- Name: Tyugyuene
 - Water system: Lena
 - Water type: River
 - Progression: Lena -> Laptev sea -> Arctic ocean -> Planet Earth
 - Climates: Continental, Subpolar
 - Continents: Asia
 - Countries: Russia
 
The Tyugyuene (Russian: Тюгюэне or Тюгене; Yakut: Түгүөнэ, Tügüöne) is a river in Yakutia (Sakha Republic), Russia. It is a tributary of the Lena with a length of 492 kilometres and a drainage basin area of 8,740 square kilometres. The river marks the border between Gorny and Kobyaysky Districts in a stretch of its middle course. The name of the river is based on the Evenk word tagin (тагин), meaning swamp.