The Uwharrie River is a 61.84 mi (99.52 km) long river, in the Piedmont region of central North Carolina in the United States.
The Uwharrie River rises in northwestern Randolph County, just south of the city of High Point, and flows generally southwardly into northwestern Montgomery County, through the low Uwharrie Mountains and the Uwharrie National Forest.
It flows into the Pee Dee River 8 mi (13 km) east of the city of Albemarle as part of the Lake Tillery reservoir, across the Pee Dee from Morrow Mountain State Park.
Above the mouth of the Uwharrie, the Pee Dee is known as the Yadkin River.
